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SAS Conference Proceedings: Pharmaceutical Users Software Exchange 2008
October 12-15, 2008, Manchester, United Kingdom, 98 papers
PhUSE 2017   PhUSE 2016   PhUSE 2015   PhUSE 2014   PhUSE 2013   PhUSE 2012   PhUSE 2011   PhUSE 2010   PhUSE 2009   PhUSE 2008   PhUSE 2007   PhUSE 2006   PhUSE 2005  

[Original source: http://www.phuse.eu/conference-2008]

Pharmaceutical Users Software Exchange 2008: Best Papers and honorable mentions

Using SAS Enterprise Guide Add-In to Enable Guided Statistics
  Bas van Bakel, OCS Consulting (Best Presentation in Applications and Software Development)
Multiple Graphs on One Page Using GREPLAY with "100% Templates"
  Dirk Spruck, Accovion (Best Presentation in Coders Corner)
Using the SAS® XML Mapper and ODS to create a PDF representation of the define.xml
  Lex Jansen, Octagon Research Solutions (Best Presentation in CDISC)
Floating Point error - what, why and how to!!
  Nigel Montgomery, Novartis Pharma AG (Best Presentation in Coding Solutions)
Efficiency Issues in Evaluating Pharmacogenetic Data With SAS
  Volker Harm, Bayer Schering Pharma AG; Stephan Lehr,Bayer Schhering Pharma AG (Best Presentation in Data Management)
Experiences of Global Working -A Japanese cutural experience
  Mako Araga, Novartis Pharma AG (Best Presentation in Professional Development and Training)
Guilty as Charged!
  Carrie Eason, Quintiles Limited; Stephanie Noller, Qunitiles Limited (Best Presentation in Posters)
Risk Based Approach Applied to the Validation of Report Objects
  Christoph Ziegler, F. Hoffmann-La Roche Ltd (Best Presentation in Regulatory)
Evaluation of Diagnostic Agents: a SAS® Macro for Sample Size Estimation Using Exact Methods
  Stefano Vezzoli, CROS NT (Best Presentation in Statistics and Pharmacokinetics)
An Animated Guide: Knowing SQL internal processes makes SQL Easy, makes SQL easy
  Russell Lavery, Numeric Resources Contractor (Best Presentation in Tutorials)

Applications and Software Development
Coders Corner
CDISC
Coding Solutions
Data Management
Professional Development and Training
Posters
Regulatory
Statistics and Pharmacokinetics
Technical Solutions
Tutorials

Applications and Software Development
tweet!  Modelling In Excel, How to Teach an Old Dog, New Tricks
  Paul Shannon, RTI Health Solutions
Pages: 10 Size: 221 Kb 
tweet!  SAS® Data via .NET®: "The Power to Show"
  Nicolas Rouillé, Mereck Sorono International
Keywords:  SAS Data Set Viszualisation  .Net  DataGridView  IOM  OLE DB 
Pages: 12 Size: 1499 Kb 
tweet!  Data Standardisation, Clinical Data Warehouse and SAS® Standard Programs
  Jean-Marc Ferran, Novo Nordisk A/S; Mikkel Traun, Functional Architect; Pia Hjulskov Kristensen, Business Implementation Specialist
Keywords:  clinical  warehouse 
Pages: 8 Size: 129 Kb 
tweet!  Automated Drug Safety Signal Detection with Guided Analysis
  Eric Brinsfield, SAS Institute; David Olaleye, SAS Institute
Keywords:  Pharmacovigilance  signal  detection  safety 
Pages: 7 Size: 176 Kb 
tweet!  Decimaker: A statistical software using R, Microsoft .NET, R (D)COM Server and graphical libraries.
  Julien Vanwinsberghe, ClinBAY, Francois Vandenhende, ClinBAY
Keywords:  R  R (D)COM Server  software  adaptive design  clinical trials  decimaker  statistical 
Pages: 10 Size: 593 Kb 
tweet!  Configuring SAS® 9 for Application Development with ASP.NET
  David Shannon, Amadeus Software Ltd
Keywords:  Web Development  Application Development  DCOM  ASP.NET  Integration Technologies 
Pages: 6 Size: 159 Kb 
Best Presentation
tweet!  Using SAS Enterprise Guide Add-In to Enable Guided Statistics
  Bas van Bakel, OCS Consulting
Pages: 9 Size: 886 Kb 
tweet!  An approach to Version Control with SAS®
  John Woods, ICON Clinical Research; Paul Crean, ICON Clinical Research
Pages: 12 Size: 443 Kb 
tweet!  Automated table generation: The macro SAS %GEEWHIZ
  Guido Wendland, UCB Pharama
Keywords:  macro 
Pages: 12 Size: 319 Kb 
tweet!  A Generalised Reporting Application based upon XML Descriptions
  Fan Shao, Mango Solutions
Keywords:  XML  Reporting  Java 
Pages: 2 Size: 109 Kb 
tweet!  Using TFL Metadata to Populate Titles & Footnotes in SAS Programs for Clinical Trials
  Stephen Hunt, ICON Clinical Research; Brian Fairfield-Carter, ICON Clincal Research
Keywords:  XML  HTA  metadata  TFLs  clinical 
Pages: 10 Size: 228 Kb 
tweet!  SHARE - A Reporting System for Efficacy Outputs using SAS® Macro
  Vinod Kaippillil Mukundaprasad, Roche
Keywords:  macro 
Pages: 9 Size: 49 Kb 
Coders Corner
tweet!  SAS macro %COUNT
  Jim Groeneveld, OCS Biometric Support
Keywords:  macro 
Pages: 8 Size: 61 Kb 
tweet!  Flexible Code Using Arrays With a Variable Name Wildcard
  Jonathan Goddard, Independent Contractor
Keywords:  array 
Pages: 4 Size: 40 Kb 
tweet!  Name Your Log with the Date & Time on Windows
  David Shannon, Amadeus Software
Keywords:  SAS Log  Date Time  Batch  Windows  DOS  Command Prompt 
Pages: 3 Size: 56 Kb 
tweet!  One Macro to Convert Variableswith Formats to Character
  Magnus Mengelbier, Limelogic Ltd; Jan Skowronski, Limelogic Ltd
Keywords:  SAS  macro  format  decode  call  execute 
Pages: 12 Size: 193 Kb 
I want it _ ALL _ ... and I want it now
  Gary Hearfield, Amgen
tweet!  Styling statistical output - A CRO perspective
  Annet te Velde, AUTHOR! Data Analysis and Reporting
Keywords:  SAS  ODS  RTF  style  template  statistical  output 
Pages: 8 Size: 56 Kb 
tweet!  Abbreviation Creation and Use: Loading an Abbreviation File
  M. Chris Moser, Contractor DataMeans; Ed Heaton, Westat; Russ Lavery, Contractor Numeric Resources
Pages: 3 Size: 44 Kb 
Best Presentation
tweet!  Multiple Graphs on One Page Using GREPLAY with "100% Templates"
  Dirk Spruck, Accovion
Keywords:  GREPLAY  multiple graphs  100%-templates 
Pages: 9 Size: 220 Kb    Download the presentationdownload (.pdf, 250 Kb)
CDISC
tweet!  The application of SDTM in a disease (oncology)-oriented organization
  Angelo Tinazzi, SENDO-Tech S.r.l ; Alessandro Cattaneo, SENDO-Tech S.r.l ; Enrica Paschetto, SENDO-Tech S.r.l ; Sonia Colombini, SENDO-Tech S.r.l
Keywords:  CDISC 
Pages: 8 Size: 510 Kb 
tweet!  CDISC Implementation Strategies: Exploit your data assets while still giving the FDA what they want
  David Smith, SAS Institute
Keywords:  CDISC 
Pages: 9 Size: 517 Kb 
tweet!  Implementing CDISC at Boehringer Ingelheim
  Michael Knoessl, Boehringer Ingelheim; Peter Leister, IBM
Keywords:  CDISC  SDTM  Clinical Data Model  Boehringer Ingelheim 
Pages: 5 Size: 61 Kb 
Best Presentation
tweet!  Using the SAS® XML Mapper and ODS to create a PDF representation of the define.xml
  Lex Jansen, Octagon Research Solutions
Keywords:  define.xml  CDISC  SDTM  SAS  XML Mapper  PDF 
Pages: 21 Size: 1258 Kb    Download the presentationdownload (.pdf, 2779 Kb)
tweet!  In at the Deep-End (thoughts on mapping multiple studies into CDISC for an ISS/ISE)
  Andrew Noller, Quintiles
Keywords:  CDISC  ISS/ ISE 
Pages: 7 Size: 170 Kb 
CDISC - an overview, How far have we come, where are we going and what is the next step
  Ann-Sofie Bergstrom, SAS Institute
Keywords:  CDISC 
CDISC SDTM, ADaM and Metadata : Connecting the Standards
  Joel Hoffman, Waban Software
Keywords:  CDISC 
tweet!  CDISC: Implementation Strategies for SDTM
  Brian Mabe, UCB Pharma
Keywords:  SAS autocall alias macro library versioning  CDISC 
Pages: 5 Size: 133 Kb 
Coding Solutions
tweet!  Just Using ODS Tables - PROC REPORT not needed!
  Philip Holland, Holland Numerics Ltd
Pages: 10 Size: 158 Kb 
tweet!  Spot the Difference
  Anja Feuerbacher, F. Hoffmann-La Roche Ltd; Beate Hientzsch, Accovion; Gabi Lückel, Accovion
Keywords:  change control  revalidation  automatic comparison 
Pages: 13 Size: 290 Kb 
tweet!  Titles and footnote management from the TLF shell to the final outputs
  Thierry Jegoux, Sanofi pasteur
Pages: 10 Size: 252 Kb 
tweet!  Creating adverse event tables using PROC SQL
  Berber Snoeijer, OCS Biometric Support
Keywords:  SQL 
Pages: 4 Size: 80 Kb 
tweet!  Alias Macros, A Flexible Versioning System for Standard SAS Macros
  Jean-Michel Bodart, UCB Pharma; Guido Wendland, UCB Pharma
Keywords:  SAS  autocall  alias  macro  library  versioning 
Pages: 7 Size: 60 Kb 
tweet!  Using JMP to CYA
  David Garbutt, Business & Decision
Keywords:  PhUSE 2008  JMP  Garbutt  Clinical Data Management  Clinical reporting 
Pages: 12 Size: 1936 Kb 
Best Presentation
tweet!  Floating Point error - what, why and how to!!
  Nigel Montgomery, Novartis Pharma AG
Keywords:  floating  point  error 
Pages: 20 Size: 249 Kb 
tweet!  Automating Elements of Validation in the Context of an ISE/ISS
  Paul Kearney, Online Success Ltd
Keywords:  automation  validation  iss  ise 
Pages: 10 Size: 33 Kb 
tweet!  GTL (Graphics Template Language) in SAS 9.2
  Philip R Holland, Holland Numerics Ltd
Pages: 8 Size: 325 Kb 
Data Management
tweet!  ETL and Data Quality: Which Comes First?
  Greg Nelson, ThotWave Technologies; Emilio Power, ThotWave Technologies
Keywords:  data quality  ETL  Data Flux  data profiling  data modeling 
Pages: 10 Size: 731 Kb 
Best Presentation
tweet!  Efficiency Issues in Evaluating Pharmacogenetic Data With SAS
  Volker Harm, Bayer Schering Pharma AG; Stephan Lehr,Bayer Schhering Pharma AG
Keywords:  pharmacogenetics data  SNP  SAS  Cochran-Armitage trend test  efficiency 
Pages: 10 Size: 112 Kb 
tweet!  Practical application of SAS® Clinical Data Integration Server for conversion to SDTM data
  Mark Lambrecht, SAS Institute; Peter Van Reusel, Business & Decision Life Sciences
Keywords:  SAS  Clinical  DI  SDTM  CDISC  conversion  clinical 
Pages: 9 Size: 418 Kb 
tweet!  Visualisation & Management of First Time in Human Safety data
  Martin Farrimond, Mango Solutions
Keywords:  first time in human  safety  data management  safety board  graphics  presentation  findings  study  preclinical  class effects  java  svg  database  oracle  application server 
Pages: 7 Size: 211 Kb 
tweet!  Migration of clincal data from IBM MVS to HP UNIX
  Fronke Gerken, Boehringer Ingelheim
Keywords:  Migration  Translation table  Character set  $VARYING. format  Input program  Rounding 
Pages: 6 Size: 350 Kb 
Professional Development and Training
tweet!  A game of snakes and ladders
  Kerry Gordon, Quintiles
Keywords:  Career development  skills development  learning  statistical programming professionals 
Pages: 6 Size: 60 Kb 
Best Presentation
tweet!  Experiences of Global Working -A Japanese cutural experience
  Mako Araga, Novartis Pharma AG
Keywords:  Cultural differences  Global working  Japanese culture 
Pages: 4 Size: 97 Kb 
tweet!  Being a lead programmer in a CRO : is it any better or worse than in a pharma company ?
  Alex Grigg, i3 Statprobe
Pages: 5 Size: 35 Kb 
tweet!  Offshoring - Have I seen this CV before
  Shafi Chowdhury, Shafi Consultancy Ltd
Keywords:  Offshoring  recruitment 
Pages: 3 Size: 25 Kb 
Global environment: Choosing the right model and partner
  Balu Ramakrishnan, Roche Products Pty Limited
tweet!  WorldWide Deployment of an Application
  Yvane Boudraa, Sanofi-Aventis Pharma; Fabienne Rouille, ABS Technologies
Pages: 4 Size: 178 Kb 
tweet!  Metrics Unleashed II: Measuring Productivity or Inspiring Artisans
  Greg Nelson, ThotWave Technologies; Mark Matthews, Eli Lilly; Neil Howard, Independent Consultant
Pages: 7 Size: 258 Kb 
tweet!  Challenges and Opportunities of working with the Pharma industry - A BPO perspective
  Dr. K.V. Palanichamy, Tata Consultancy Services Ltd; Samidha Sawant, Tata Consultancy Services Ltd; Anagha Bhatkhande Tata Consultancy Services Ltd; Balu Ramakrishnan, Roche Products Limited
Pages: 7 Size: 62 Kb 
tweet!  The X-Factor - Recruiting the Best
  Rachel Bowman, AstraZeneca
Keywords:  programmer  recruitment 
Pages: 5 Size: 20 Kb 
Posters
tweet!  Pharmacokinetics for the Non-Specialist
  Harpreet Rattan, Roche Products Limited
Pages: 1 Size: 93 Kb 
tweet!  Enriching decision making through data integration: Creating a project database (PDb)
  Jennifer Lomax, AstraZeneca, Nicki Noble, AstraZeneca
Pages: 4 Size: 37 Kb 
tweet!  %RTFParser
  Duong Tran, Tranz Ltd
Pages: 4 Size: 41 Kb 
tweet!  Improving the Quality of Data
  Hester Schoeman, Covance CAPS Ltd.
Keywords:  Improving  Quality  SAS  Stored  Process 
Pages: 7 Size: 419 Kb 
tweet!  EXCEL 2 SAS
  Duong Tran, Tranz Ltd
Pages: 6 Size: 85 Kb 
tweet!  Weigh-up your SAS® skills : Certification Vs. Experience
  Amar Najib, Citibank; Donna Thompson, AstraZeneca
Pages: 4 Size: 57 Kb 
tweet!  Missing Data in Cross-Over Trials
  Edyta Mrowka, Quanticate
Pages: 7 Size: 165 Kb 
tweet!  How big? Oh my... it's time to prepare
  Julie Oates, GSK
Pages: 4 Size: 160 Kb 
tweet!  Let SASHELP Help You
  Catriona O'Hare, ICON Clinical Research
Pages: 8 Size: 214 Kb 
Best Presentation
tweet!  Guilty as Charged!
  Carrie Eason, Quintiles Limited; Stephanie Noller, Qunitiles Limited
Pages: 1 Size: 231 Kb 
tweet!  A graphical approach to Examine the Completeness of Epidemiological Data: Patient Profile Plots (PPPs) and Centre Profile Plots (CPPs)
  Methodios Typou, Independent Consultant; Joseph Kim, Amgen
Keywords:  SAS/GRAPH  Patient Profile  Epidemiological data  Observational research 
Pages: 1 Size: 352 Kb 
tweet!  An Animated Guide: The Logical Cascade through the --ORRES Variable
  Russell Lavery, Numeric Resources
Pages: 13 Size: 363 Kb 
tweet!  Run Forest ! Run ! Create a flexible Forest Plots with SAS® Enterprise Guide.
  Emmanuel Bourmaud, Keyrus Biopharma; Adrien Valee, Keyrus Biopharma; Gwenael Le Teuff, Keyrus Biopharma
Keywords:  SAS ENTERPRISE GUIDE  GRAPH  ANNOTATE  FOREST PLOT  META-ANALYSIS 
Pages: 12 Size: 173 Kb 
tweet!  Statistics for Non-Statisticians
  Shambhavi Nayak, Quanticate Ltd
Pages: 10 Size: 106 Kb 
tweet!  Biostatistics and Data Management - A match made in ....Tasmania?
  Elaine Dempsey, Omnicare Clinical Research
Pages: 2 Size: 73 Kb 
Regulatory
tweet!  RECIST Temptation
  Paul Jenkins, Quintiles
Keywords:  RECIST  programming  guidelines  lesions 
Pages: 8 Size: 106 Kb 
Best Presentation
tweet!  Risk Based Approach Applied to the Validation of Report Objects
  Christoph Ziegler, F. Hoffmann-La Roche Ltd
Pages: 8 Size: 210 Kb 
tweet!  Automating Production of Validation Documentation
  Tangi Sanséau, ICON Clinical Research
Keywords:  Validation  Documentation  -  Authorities  Requirements  -  Automating 
Pages: 10 Size: 565 Kb 
tweet!  Developing a clinical reporting system collaboratively under an Open Source software license.
  Ann M. Martin, UCB Pharma
Keywords:  clinical 
Pages: 7 Size: 29 Kb 
tweet!  Validation of Clinical Output: More Quality with Less Effort
  Jules van der Zalm, van der, OCS Biometric Support
Keywords:  clinical 
Pages: 7 Size: 352 Kb 
tweet!  Automatic Unit Testing of SAS programs with SASUnit
  Andreas Mangold, HMS Analytical Software GmbH; Patrick René Warnat, HMS Analytical Software GmbH
Keywords:  Testing  Unit Test  Quality  Software Engineering  SAS/BASE  SAS/Macro  GxP Compliance 
Pages: 11 Size: 399 Kb 
tweet!  Drug Safety Reporting - now and then
  David Garbutt, Business & Decision
Pages: 22 Size: 1456 Kb 
Statistics and Pharmacokinetics
tweet!  Exchange of Information for the Statistical Analysis and Reporting of PK Parameter Data
  Ann Cuijpers, J&JPRD; Sarah Rusch, J&JPRD; Iris Van de Vliet, J&JRPD
Pages: 2 Size: 87 Kb 
Best Presentation
tweet!  Evaluation of Diagnostic Agents: a SAS® Macro for Sample Size Estimation Using Exact Methods
  Stefano Vezzoli, CROS NT
Keywords:  sample  size  diagnostic  test  exact  method  macro  binomial  proportion 
Pages: 8 Size: 360 Kb 
tweet!  A gentle introduction to Survival Analysis
  Angelo Tinazzi, SENDO Tech S.r.l.; Martin Scott, Numerous Limited; Anna Compagnoni, SENDO Tech S.r.l.
Pages: 13 Size: 255 Kb 
tweet!  How to produce Forrest-plots with PROC GPLOT and Annotate facility
  Laetitia Lemoine Le Halpert, Quintiles
Pages: 8 Size: 108 Kb 
tweet!  Concepts and Ideas for Developing and Maintaining a Utility Toolbox of SAS Statistical Procedures
  David Carr, ICON Clinical Research
Keywords:  SAS  PROC FREQ  CHI-SQUARE  PROC MIXED  PROC NPAR1WAY  KRUSKAL-WALLIS  PROC LIFETEST  KAPLAN-MEIER  ANOVA 
Pages: 6 Size: 157 Kb 
tweet!  Statistically guided review of safety data in clinical trials
  Michael O'Connell, ITIBCO Spotfire; Harry Southworth, AstraZeneca
Keywords:  Bayesian  S-PLUS  safety  open source  WinBugs  clinical 
Pages: 12 Size: 458 Kb 
tweet!  A Collection of SAS Macros to Calculate Odds Ratios using Spline Regression
  Martin Gregory, Merck Serono
Keywords:  spline  regression  macro  odds ratio 
Pages: 9 Size: 146 Kb 
Technical Solutions
tweet!  J(u)mp to R: Using R functions in JMP Genomics
  Patrick René Warnat, HMS Analytical Software GmbH; Friedrich Schuster, HMS Analytical Software GmbH; Andreas Mangold, HMS Analytical Software GmbH
Pages: 6 Size: 49 Kb 
tweet!  SYMBOL TYPE AND COLOUR IN GRAPHS
  Diederik Pietersma, AstraZeneca
Keywords:  graphics  visualization 
Pages: 7 Size: 258 Kb 
tweet!  Delivering Statistics - a Workflow Supported by the SAS Stored Processes
  Volker Harm, Bayer Schering Pharma AG
Keywords:  SAS Stored Process  SAS Information Delivery Portal  proc glm  ods 
Pages: 8 Size: 206 Kb 
tweet!  SAS® Talking via the Java Object Interface
  Magnus Mengelbier, Limelogic Ltd; Jan Skowronski, Limelogic Limited
Keywords:  SAS  java  object  interface  integration  chunking  soap  web  service  jdbc 
Pages: 10 Size: 195 Kb 
tweet!  Kept in Translation: Avoiding Data Loss and Other Problems When Converting Japanese Data
  Steve Prust, Covance
Keywords:  DBCS  Unicode  Translation  Japanese 
Pages: 9 Size: 158 Kb 
tweet!  SAS and LaTeX - A perfect match?
  Juha-Pekka Perttola, F. Hoffmann-La Roche AG
Keywords:  SAS  LaTeX 
Pages: 12 Size: 138 Kb 
tweet!  SAS macros for S-PLUS Clinical Graphics within a Production Reporting Environment
  Sven Jesper Knudsen, TIBCO Spotfire; Charlie Roosen, TIOBCO Spotfire
Keywords:  macro  clinical 
Pages: 4 Size: 213 Kb 
tweet!  Dynamic Decimal Precision and Alignment in Clinical Trial Summary Tables and Patient Data
  Stephen Hunt, ICON Clinical Research; Brian Fairfield-Carter, ICON Clinical Research
Keywords:  Decimal Alignment  Numeric Precision  Reporting  clinical 
Pages: 8 Size: 143 Kb 
tweet!  A Graphical Approach to Examine the Completeness of Epidemiological Data: Patient Profile Plots (PPPs) and Centre Profile Plots (CPPs)
  Methodios Typou, Aeolus Consultancy Limited; Joseph Kim, Amgen
Keywords:  SAS/GRAPH  Patient Profile  Epidemiological data  Observational research 
Pages: 14 Size: 339 Kb 
tweet!  Getting More from the Compute Block to Enhance Table & Listing Output for Clinical Trials Reporting
  David Carr, ICON Clinical Research
Keywords:  SAS  PROC REPORT  COMPUTE BLOCK  clinical 
Pages: 6 Size: 184 Kb 
Tutorials
tweet!  Today's Project Management Software: It's Easier Thank You Think!
  Jenny Gandhi, Quanticate International Ltd
Pages: 10 Size: 432 Kb 
tweet!  XML by eXaMpLe
  Raymond Ebben, OCS Consulting
Keywords:  xml 
Pages: 12 Size: 303 Kb 
tweet!  Professional outputs with ODS LATEX
  Arnaud Dauchy, Sanofi-Aventis; Solenn Le Guennec, Sanofi-Aventis
Pages: 8 Size: 167 Kb 
tweet!  Applying SMQs to Adverse Event Data
  John van Bemmelen, Schering-Plough
Keywords:  SMQ  MedDRA  queries  AE  broad  narrow  algorithmic 
Pages: 10 Size: 559 Kb 
tweet!  An introduction to ODS Statistical Graphics
  Ian Sedgwick, SAS
Keywords:  Statistical Graphics  ODS Graphics  GTL  Styles  SAS 9.2 
Pages: 15 Size: 311 Kb 
Best Presentation
tweet!  An Animated Guide: Knowing SQL internal processes makes SQL Easy, makes SQL easy
  Russell Lavery, Numeric Resources Contractor
Keywords:  SQL 
Pages: 18 Size: 157 Kb 
tweet!  ... but there are no ERROR messages in the LOGs
  Shafi Chowdhury, Shafi Consultancy Ltd
Keywords:  ERRORS  REPEATS OF BY  W.D 
Pages: 11 Size: 72 Kb 
tweet!  Using SAS®9 in Clinical Research
  Greg Nelson, ThotWave Technologies
Keywords:  clinical 
Pages: 11 Size: 411 Kb 
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